Thesis Topic Details

Topic ID:
2913
Title:
The effect of antigen presentation on the T cell mediated immune response
Supervisor:
Fabio Luciani
Research Area:
Theory, Bioinformatics, Modelling
Associated Staff
Assessor:
Bruno Gaeta
Topic Details
Status:
Active
Type:
Research
Programs:
CS BIOM BINF
Group Suitable:
No
Industrial:
No
Pre-requisites:
Java, basics of immunology/biiology
Description:
This project is based on on-going collaboration with Prof. Chen from the Ludwig Cancer Institute in Melbourne.
The goal is to improve an already established Java program to simulate the dynamics of T cell response considering competition phenomena. For instance, in order to be activated, T cells have to recognise infected cells. This recognition mechanism is mediated by the presentation of viral proteins on the surface of infected cells. T cells are able to recognise the virus-specific information by binding their receptors to the infected cells that present the viral antigen.
The proposed project aims to quantitaively analyse these recognition patterns and investigate the role of competition between different T cells for binding to viral proteins.
Upon interest, the student can also develop a more advanced program to introduce the memory T cell pool, which has a great impact on the reseach aimed to design vaccines against intracellular viruses.
Comments:
please, fill free to contact me for explanations and more detailed questions.
email luciani@unsw.edu.au
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