Thesis Topic Details

Topic ID:
2968
Title:
Bioinformatic analysis of low molecular weight heparin
Supervisor:
John Whitelock
Research Area:
Biomedical Engineering, Bioinformatics, Biochemistry and immunology
Associated Staff
Assessor:
Topic Details
Status:
Active
Type:
R & D
Programs:
BIOM BINF
Group Suitable:
No
Industrial:
Yes
Pre-requisites:
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Description:
Heparin, and the less sulfated counterpart heparan sulfate, are important for the control of many biological processes including coagulation and growth factor delivery. The precise structure of these biological polymers is largely unknown and required in order for tissue engineering strategies to be developed for the targeted delivery of growth factors. This project involves the isolation of heparin and heparan sulfate structures from biological sources and performing bioinformatic and biochemical analyses on them to elucidate active structures. The project involves working closely with engineers and matrix biology researchers within the Graduate School of Biomedical Engineering, consisting of researchers at the undergraduate, postgraduate and postdoctoral level. An understanding of the specific heparin sequences required for modulating tissue function for inclusion in tissue engineered materials. The candidate will gain valuable experience in the bioinformatic analysis of biological materials as well as biochemical characterisation assays.
Comments:
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Past Student Reports
  Jeffrey JONG in s1, 2011
Bioinformatic analysis of low molecular weight heparin
 

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