Thesis Topic Details

Topic ID:
2994
Title:
Evolution of Redox-regulation of Cys Residues in Proteins
Supervisor:
Merridee Wouters
Research Area:
Associated Staff
Assessor:
Bruno Gaeta
Topic Details
Status:
Active
Type:
Research
Programs:
BINF
Group Suitable:
No
Industrial:
Pre-requisites:
An interest in proteins and protein structure. Ability to program in perl. Familarity with a Unix-based environment.
Description:
Early studies on protein sequences indicated Cys is more abundant in more complex organisms. This has been confirmed by more recent studies on whole genomes, that have shown that the abundance of Cys in proteins has been increasing since divergence from the Last Universal Ancestor and this increase is a continuing pan-species phenomenon which is evident within the last 10 million years. Thus increased usage of Cys correlates with increased organismal complexity. The project aims to investigate the hypothesis that increased Cys is related to increased redox-regulation, and that additional complexity added to protein domains in the form of redox switches likely increase the signaling capabilities of these domains.
Comments:
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