Thesis Topic Details
Topic ID: |
2994 | |
Title: |
Evolution of Redox-regulation of Cys Residues in Proteins | |
Supervisor: |
Merridee Wouters | |
Research Area: |
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| Associated Staff | ||
|---|---|---|
Assessor: |
Bruno Gaeta | |
| Topic Details | ||
Status: |
Active | |
Type: |
Research | |
Programs: |
BINF | |
Group Suitable: |
No | |
Industrial: |
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Pre-requisites: |
An interest in proteins and protein structure. Ability to program in perl. Familarity with a Unix-based environment. | |
Description: |
Early studies on protein sequences indicated Cys is more abundant in more complex organisms. This has been confirmed by more recent studies on whole genomes, that have shown that the abundance of Cys in proteins has been increasing since divergence from the Last Universal Ancestor and this increase is a continuing pan-species phenomenon which is evident within the last 10 million years. Thus increased usage of Cys correlates with increased organismal complexity. The project aims to investigate the hypothesis that increased Cys is related to increased redox-regulation, and that additional complexity added to protein domains in the form of redox switches likely increase the signaling capabilities of these domains. |
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Comments: |
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| Past Student Reports | ||
| No Reports Available. Contact the supervisor for more information.
Check out all available reports in the CSE Thesis Report Library. NOTE: only current CSE students can login to view and select reports to download. |
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