Thesis Topic Details
Topic ID: |
3033 | |
Title: |
Using bioinformatics to assess the post translational modifications that control the bioactivity of growth factors. | |
Supervisor: |
John Whitelock | |
Research Area: |
Biomedical Engineering, Bioinformatics, Biochemistry and immunology | |
| Associated Staff | ||
|---|---|---|
Assessor: |
Marc Wilkins | |
| Topic Details | ||
Status: |
Active | |
Type: |
Research | |
Programs: |
BIOM BINF | |
Group Suitable: |
No | |
Industrial: |
No | |
Pre-requisites: |
-- | |
Description: |
Fibroblast growth factors (FGF) bind to heparin containing molecules via positiely charged amino acid residues. This binding modulates the downstream FGF receptor activation leading to intracellular activation of pathways involved in cell migration and proliferation. This project will use bioinformatic analyses based on well known algoriths to assess the possibility of post translational modification of the basci amino acids. We will then obtain FGF from different commercial sources and perform mass spectrometry to see whether these modifications actually exist. Finally, the project will explore the effects of these modifications on binding and activating FGF receptors using biochemical, immunochemical and cell based approaches. |
|
Comments: |
-- | |
| Past Student Reports | ||
| No Reports Available. Contact the supervisor for more information.
Check out all available reports in the CSE Thesis Report Library. NOTE: only current CSE students can login to view and select reports to download. |
||