Thesis Topic Details

Topic ID:
3033
Title:
Using bioinformatics to assess the post translational modifications that control the bioactivity of growth factors.
Supervisor:
John Whitelock
Research Area:
Biomedical Engineering, Bioinformatics, Biochemistry and immunology
Associated Staff
Assessor:
Marc Wilkins
Topic Details
Status:
Active
Type:
Research
Programs:
BIOM BINF
Group Suitable:
No
Industrial:
No
Pre-requisites:
--
Description:
Fibroblast growth factors (FGF) bind to heparin containing molecules via positiely charged amino acid residues. This binding modulates the downstream FGF receptor activation leading to intracellular activation of pathways involved in cell migration and proliferation.
This project will use bioinformatic analyses based on well known algoriths to assess the possibility of post translational modification of the basci amino acids. We will then obtain FGF from different commercial sources and perform mass spectrometry to see whether these modifications actually exist. Finally, the project will explore the effects of these modifications on binding and activating FGF receptors using biochemical, immunochemical and cell based approaches.
Comments:
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Past Student Reports
 
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