Thesis Topic Details

Topic ID:
3347
Title:
Evolution of CLIC and ERM proteins
Supervisor:
Paul Curmi
Research Area:
Bioinformatics
Associated Staff
Assessor:
Bruno Gaeta
Topic Details
Status:
Active
Type:
Research
Programs:
BINF
Group Suitable:
No
Industrial:
No
Pre-requisites:
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Description:
The organisation of single celled eukaryotes into metazoa is one of the most profound events in evolution. There are proteins that are characteristic of metazoa which may have been responsible for cellular processes that facilitated multicellularity. This project aims to explore the origin and evolution of two such proteins. These are the CLIC family and the ERM family (ezrin, moesin and radixin). Current data on mammalian cells indicate that these two families my interact functionally and coordinate the coupling of membranes to the cortical actin cytoskeleton. To date, the only unicellular eukaryotes to carry ERM proteins appear to be the choanoflagellates. These are believed to be the closest unicellular relatives to metazoa.

This project will involve the exploration of the evolution of both CLIC and ERM proteins. BLAST tools will be used to construct extensive data sets of family members. These will be aligned and phylogenetic trees constructed. The evolution of the two families will be compared to find evidence for co-evolution. We will also examine the evolution of other proteins that are thought to be functionally related to CLICs and ERM. The aim is to establish a network of evolutionarily coupled protein families. This will enhance our knowledge of the biological function of these proteins. Of particular interest is the role of each of these protein families in the unicellular choanoflagellates. We will explore the emerging genome sequences of these organisms.



Comments:
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Past Student Reports
  Shraddha RAMAKRISHNAN in s1, 2013
Evolution of CLIC and ERM proteins
 

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