Thesis Topic Details

Topic ID:
3464
Title:
Integrative analysis of histone-modifying enzymes' expression program
Supervisor:
Joshua Ho
Research Area:
Bioinformatics, Biochemistry, Systems biology
Associated Staff
Assessor:
Bruno Gaeta
Topic Details
Status:
Active
Type:
Research
Programs:
CS CE BIOM BINF SE
Group Suitable:
No
Industrial:
Yes
Pre-requisites:
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Description:
Chemical modifications of core histone proteins - the main constituents of nucleosomes - are pertinent for gene regulation. Histone modification is mediated by various histone-modifying enzymes, and mutation of these enzymes has been implicated in many cancers. Nonetheless the expression patterns of this important class of proteins have not been systematically studied. This project will employ a systems biology approach to reconstruct a gene regulatory network of histone-modifying enzymes, and study their expression program by compiling and analysing a compendium of gene/protein expression data using public bioinformatic databases.
Comments:
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Past Student Reports
 
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