Thesis Topic Details

Topic ID:
3467
Title:
Gene regulatory network in embryonic organ development
Supervisor:
Joshua Ho
Research Area:
Bioinformatics, Machine Learning, Systems biology
Associated Staff
Assessor:
Bruno Gaeta
Topic Details
Status:
Active
Type:
Research
Programs:
CS CE BIOM BINF SE
Group Suitable:
No
Industrial:
Yes
Pre-requisites:
--
Description:
One central question in embryology is 'What is the molecular mechanism that mediates the step-wise and coordinated developmental program?' Our group tackles this question from a systems biology perspective - a growing field called 'developmental systems biology'. Many organs form via intercellular exchange of signaling molecules and an intracellular network of transcription factors. These interactions can be summarised into a gene regulatory network (GRN). We recently developed a probability graphical modeling approach to reconstruct the development of multiple embryonic organs. For example, we have already collected data for tooth, salivary glands, pancreatic islets, ocular lens and heart valves. This project will involve refinement and extension of this statistical method to reconstruct GRN in one or more developing organs. This project will involve close collaboration with local and international developmental biologists.
Comments:
--
Past Student Reports
 
No Reports Available. Contact the supervisor for more information.

Check out all available reports in the CSE Thesis Report Library.

NOTE: only current CSE students can login to view and select reports to download.