Thesis Topic Details

Topic ID:
3532
Title:
Developing methods and tools for constructing a 3D chromosomal structure using homology methods and other structural prediction techniques
Supervisor:
Socrates Dokos
Research Area:
Bioinformatics, Genome informatics, Systems biology
Associated Staff
Assessor:
Bruno Gaeta
Topic Details
Status:
Active
Type:
Research
Programs:
BINF
Group Suitable:
No
Industrial:
No
Pre-requisites:
--
Description:
Due to the large length of the chromosome (about 250 million base pairs in Chromosome 1 of the human genome) and lack of experimental data for the structure of the genome, the entire physical genomic structure has never been modelled in full detail. Knowledge of its structure is important for determining gene-gene interactions and protein-gene interactions.
The goal of this project is to discover methods for constructing the 3D structure of the chromosome using existing data on gene interactions with other genes and with proteins and homology methods to match similar motifs.
Comments:
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Past Student Reports
 
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