Base 16 (hexadecimal) is useful because it is easy to convert to or from binary and it is more compact that binary.
Letters A, B, C, D, E, F used to represent 10, 11, 12, 13, 14, 15
3EA916 = 3*163 + 14*162 + 10*161 + 9*160
= 3*4096 + 14*256 + 10*16 + 9*1
= 12288 + 3584 + 160 + 9
= 16041