iHMMune-align Change Log
10th, January, 2008
- Added fix for use of custom scoring matrices
7th, Sepember, 2007
- Added the dprob column to the CSV output header as it was missing
- Fixed display of hotspots whose nucleotides span across the gaps introduced to allow for IMGT numbering of the IGHV region
- Updated the output options and the output documentation pages
6th, September, 2007
- Added description of Combined Repertoire Option
- Fixed 'fatal error' that was resulting when attempting to display mutation information for sequences with stop codons present
- Edited gapping template and combined repertoire files to ensure consistient nomenclature with the IGHV-R1, as inconsistiencies
were causing some sequences not to be gapped
- Added contact emails to the navigation menu
2nd, September, 2007
- Altered iHMMune-align to correctly output multiple IGHV (if requested) for sequences where the first IGHV found has gaps present
- Added option to use choose between the IGHV Expressed Repertoire and a combined repertoire based on merging of the iHMMune-align, IMGT
and VBASE2 repertoires
- Added IMGT numbering of mutation output for the IGHV of input sequences
- Added CDR/FR delimiters to the IGHV for mutation display
- Edited general site layout, simplified iHMMune-align submission form and added download section
23rd, July, 2007
- Fixed an error that was preventing the return of alignments where the input sequences was lacking either the N1 or N2 region
11th, July, 2007
- Altered iHMMune-align to identify gaps in the input sequence, HMM not yet able to deal with gaps but prints message to
indicate their presence
- Fixed rounding of IGHD misidentification probabilities to improve display
- Fixed problems with display of mutation alignment when multiple IGHV are being displayed for a single sequence
9th, July, 2007
- Added 'Dynamic' option for determination of IGHD gene identification criteria
- Added IGHD misidentification probabilities (as described in Jackson, 2007)
to the iHMMune-align algorithm
- Fixed in-line table errors that were causing display problems in Microsoft Internet Explorer
6th, July, 2007
- Added mutation display and summary of mutation paths as an output option
- Updated iHMMune-align algorithm to allow return of multiple IGHV alternatives for a sinlge input sequence
7th, June, 2007
- Added save button to results page to download CSV results as a text file to local computer
- Fixed 'Summary of Results' display for sequences that lack an indentifiable IGHD
- Added documentation pages: minJ, range, seqs per run, IGHD identification
- Added 'HTML' as an output format option
- Added 'header' to CSV output to describe column contents
31st, May, 2007
- Changed Scoring Matrix options to a drop down box
- Added output of iHMMune-align execution details to a text area when an error occurs to make trouble shooting easier
- Changed 'Output Summary' to side-by-side box design
30th, May, 2007
- First version of iHMMune-align Web-based access
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