BINF3001 08s2

Computational Modelling of Biological Systems


Lecture slides

Introduction

Biological networks as graphs

Motifs and Modules

Modelling approaches


Assignment

Overview papers

Modelling cellular behaviour

Computational systems biology

Biological Networks: The Tinkerer as an Engineer

Can a biologist fix a radio? - Or, what I learned while studying apoptosis

Hints and Guidelines

How to read a scientific paper

Presentations and Reports

Assignment papers grouped by topic

Petri Nets

Modelling biological processes using workflow and Petri Net models

Hybrid Petri Net representation of gene regulatory networks

Quantitative modeling of stochastic systems in molecular biology by using stochastic Petri nets

Methods Based on Differential Equations

Foundations of a query and simulation system for the modeling of biochemical and biological processes

Metabolic Pathway Analysis: Basic Concepts and Scientific Applications in the Post-genomic Era

Prediction of mutant expression patterns using gene circuits

Structure and function of the feed-forward loop network motif

Bayes Nets

Using Bayesian Networks to Analyze Expression Data

Using graphical models and genomic expression data to statistically validate models of genetic regulatory networks

Inferring Subnetworks from Perturbed Expression Profiles

Discovery of Causal Relationships in a Gene-regulation Pathway from a Mixture of Experimental and Observational DNA Microarray Data

Logical Methods

Developing a Logical Model of Yeast Metabolism

Combining Inductive Logic Programming, Active Learning and Robotics to Discover the Function of Genes

Functional genomic hypothesis generation and experimentation by a robot scientist

Abductive Inference of Genetic Networks

A knowledge based approach for representing and reasoning about signaling networks

Cellular Circuits

The Computational Versatility of Proteomic Signaling Networks

Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell

Modeling transcriptional regulatory networks

Design of gene circuits: lessons from bacteria

Robustness in simple biochemical networks

Network Motifs

The Coherent Feedforward Loop Serves as a Sign-sensitive Delay Element in Transcription Networks

Negative Autoregulation Speeds the Response Times of Transcription Networks

Genomic analysis of regulatory network dynamics reveals large topological changes

An extended transcriptional regulatory network of Escherichia coli and analysis of its hierarchical structure and network motifs

Just-in-time transcription program in metabolic pathways

Network motifs in integrated cellular networks of transcription-regulation and protein-protein interaction